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Ideally this post in producing online businesses will assist you to any time creating numerous sites. There are numerous various kinds of online businesses but much of these people conclude precisely the same type of vast classes: marketing upon craigs list, list sites, solutions sites, as well as business-to-business sites. You perform inside distinct classes effortlessly however make sure you acquire everything you study from every single various class as well as use it?s within your additional undertakings.
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Mar. 5, 2013 ? New research from Rice University, Baylor College of Medicine (BCM) and the Puget Sound Blood Center (PSBC) has revealed how stresses of flow in the small blood vessels of the heart and brain could cause a common protein to change shape and form dangerous blood clots. The scientists were surprised to find that the proteins could remain in the dangerous, clot-initiating shape for up to five hours before returning to their normal, healthy shape.
The study -- the first of its kind -- focused on a protein called von Willebrand factor, or VWF, a key player in clot formation. A team led by Rice physicist Ching-Hwa Kiang found that "shear" forces, like those found in small arteries of patients with atherosclerosis, cause snippets of nonclotting VWF to change into a clot-forming shape for hours at a time. The finding appears online this week in Physical Review Letters.
"When I first heard what Dr. Kiang's team had found, I was shocked," said blood platelet expert Dr. Joel Moake, a study co-author who holds joint appointments at Rice and BCM. Moake, whose research group was the first to describe how high shear stress could cause platelets to stick to VWF, said, "I had thought that the condition might last for such a short time that it would be unmeasurable. No one expected to find that this condition would persist for hours. This has profound clinical implications."
Kiang, associate professor of physics and astronomy and of bioengineering, studies the forces involved in protein folding. Proteins are the workhorses of biology. Tens of thousands are produced each second in every living cell, and each of these folds into a characteristic shape within moments of its creation. Despite its ubiquity, protein folding is an immensely complex process that is shrouded in mystery.
Kiang is a pioneer in the use of atomic force microscopes (AFM) to shed light on the fundamental physical processes involved in protein folding. The AFM has a tiny needle with a tip measuring just a few atoms across. The needle is suspended from a tiny arm that bobs up and down over a surface. Kiang's team uses the bobbing needle to grab and pull apart individual protein molecules. By stretching these like rubber bands, her team has shown it can measure the precise physical forces that hold them in their folded shape.
"In this study, we did more than just measure the forces; we used those measurements to see what state the molecule was in," Kiang said. "In this way, we were able to study the dynamics of the molecule, to see how it changed over a period of time."
Moake, a senior research scientist in bioengineering at Rice and professor of medicine at BCM, said the work is vitally important because it helps explain the workings of VWF.
"VWF is synthesized in the cells that line the walls of blood vessels, and it's stored there until the cells get signals that the vessels are in danger of injury," Moake said. "In response to those stimuli, the cell secretes VWF. It's a long protein, and one end remains anchored to the cell while the rest unfurls from the wall like a streamer."
The act of unfurling makes VWF sticky for platelets, and that begins the process of hemostasis, which prevents people from bleeding to death when blood vessels are damaged by cuts and wounds.
"The body recognizes when clotting must stop -- when there are too many strings, too much sticking, too many platelet clumps -- and it uses an enzyme to clip the long VWF strings," Moake explained. "First, it makes large, soluble versions of the strings that remain somewhat sticky, and then these large soluble portions of VWF are reduced into smaller subunits of VWF that circulate in the plasma."
Under normal conditions, these circulating subunits, which are called PVWF, fold into compact shapes and cease to be sticky to platelets. However, previous research had shown that a type of physical stress called "shear" -- which can arise in partially occluded arterial blood vessels with high flow rates -- could cause PVWF to become sticky to platelets.
"That's all we knew," Moake said. "We didn't know how the conformation of the PVWF protein changed. That is why Dr. Kiang's research is so important and makes it more likely that therapeutic interventions can be more rationally designed."
To study the problem, Kiang's lab worked closely with Moake's team at Rice's BioScience Research Collaborative and with researchers from the laboratory of co-author Jing-fei Dong, formerly of BCM and now at PSBC in Seattle. Moake's and Dong's groups prepared samples of PVWF, subjecting some to the shear stresses known to induce clot formation. Kiang's team used AFMs to test the samples. Through a combination of experiments and deductive reasoning, her team determined exactly which portion of PVWF changed its conformation during shear stress. They also determined how long the protein remained partially unfurled before relaxing into its natural shape.
"The next step will be to design new experiments that allow us to monitor the proteins as they bind to platelets and initiate clot formation," Kiang said. "That will tell us even more about the physical properties of the proteins and provide more clues about potential therapies."
The research was supported by the National Institutes of Health, the National Science Foundation, the Alliance for NanoHealth, the Welch Foundation, the Mary R. Gibson Foundation and the Everett Hinkson Fund. Study co-authors include Rice graduate students Sithara Wijeratne and Eric Frey, former Rice graduate student Eric Botello, BCM researchers Hui-Chun Yeh and Angela Bergeron, Rice undergraduate Jay Patel, PSBC's Zhou Zhou and Rice senior research technicians Leticia Nolasco and Nancy Turner.
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The above story is reprinted from materials provided by Rice University. The original article was written by Jade Boyd.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Sithara S. Wijeratne, Eric Botello, Hui-Chun Yeh, Zhou Zhou, Angela L. Bergeron, Eric W. Frey, Jay M. Patel, Leticia Nolasco, Nancy A. Turner, Joel L. Moake, Jing-Fei Dong, and Ching-Hwa Kiang. Mechanical Activation of a Multimeric Adhesive Protein Through Domain Conformational Change. Physical Review Letters, 2013 DOI: 10.1103/PhysRevLett.110.108102
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Author: Greg James | Total views: 91 Comments: 0 Word Count: 1082 Date:
Many people who start a website never think about where their data is stored. This is the point where knowledge about web hosting will help. A lot of people starting out should know what designs they can have and what options they have. This article has many tips for new site owners on choosing a good web host.
Your web host should play a key role in your site management, by offering you tools that allow you to track and analyze site statistics like traffic. Independently add a traffic counter somewhere on your website, then compare its results to those that are provided by your host. To maximize the effectiveness of your web site, this information can help you tailor your marketing approaches.
Always keep in mind the frequency that outages occur with a company prior to selecting one. Never accept any excuses that a company may give you for them. There are companies that will defer electrical outages, or give you a million reasons for their poor pop up time, though if you have a really good company, they will do whatever it takes to keep your website up and running. No matter what you are paying for the service, or if they happen to be highly recommended, do not stand for their excuses.
Find a web host that is very effective when it comes to communication. A company who stays connected to its customers is one you will need, and one who informs you of issues, maintenance times or new features. It is also important to have easy contact and to receive a quick response in case you have any problems.
Ensure that you're reading reviews on the web hosts you're considering prior to selecting one. You'll find reviews which mention horribly bad service and exceptionally good service, although rarely any in between. Once you've read all the reviews you can find, you can make an informed decision and go with a well-respected company.
Avoid falling for scams and hidden costs. Many hosts will show low prices on their plan advertisements, but they never tell you about the fees you'll have tacked on top of that price. That is why it is imperative that you learn is included in any hosting plan you are considering. You should also consider the features you are likely to use. Do your best to pick a plan that only covers exactly what you need to have in order to ensure a fair price.
The company you choose must be one that will accommodate your future needs. One page of HTML doesn't require much space, but as you make your site more complex by adding images and video, your space requirement will grow rapidly. Having access to 100MB of storage space should give you enough room to develop your site.
It is useful to get a glimpse of the control panel and navigational design of your hosting provider. A web host that is worth it, should give you directions on walking you through setting up your site. Don't sign up with a service if the control panel seems too hard for you to learn. Find another service that has simpler controls.
Avoid hosting your website with a dial-up connection. This is too outdated for the modern Internet. To keep your website stable and current, back it by a reliable and constant connection source. Otherwise, downtime and lags will hinder your site and may even bring it offline.
Your web host should be the recipient of plenty of hosting awards. You can utilize this information to gauge service. Most of these awards are achieved through the legitimate process of site visitors voting, and they are a good indication that the hosting company is a good one with which to work. Hosts with a number of awards voted for by customers are the ones you should go with.
A superior web hosting service may allow you to cancel at will. Reputable companies will often give you the option to end your contract early and will refund your money for unused services. No web host should make you feel like you are trapped.
Make sure the web host you choose offers support for every programming language used by your website, as well as any you may end up using in the future. It will be a hard task to start up your website, if you are trying to run it using a language that your hosting company doesn't support. In addition, if you decide to use a programming language in the future that is not supported, it is very likely that your web host will not be able to accommodate. Changing hosts can be a bothersome task.
Remember that you often get what you pay for with free hosting sites. Most free hosts require your site to carry ads. You will have absolutely no say in what sort of advertising appears on your website. Advertising for a variety of products on your site, will make it appear untrustworthy and unprofessional.
Plan on paying for a high quality web-host. Although free web hosts are useful for some, a business website hosted on these servers may be viewed as unprofessional. Many of the free web hosting providers will place ads on your website which you may not have control of. Ads which place themselves all over your site will annoy your visitors and drive traffic away.
Know your web host's maintenance schedule. The best situation is when the routine maintenance is only scheduled once a month. If you choose the web host this will put a limit on any down time you will have on your business.
It is vital that the hosting service you choose has all of the services and features that you need and want for your website. SSL certificates, software compatibility and email filtering are all useful applications that should be included in any basic service package.
This article has hopefully shown you that there's more to setting up your website than choosing the domain name. You have to find a service to host it. The more you know about the features and benefits of different web hosting options, the easier it will be to operate your website efficiently. Use the advice from this article to quickly get your site running.
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1: Understanding Online Business Success
Starting a home based business to earn income online takes a significant amount of time and energy upfront to get things going. Not seeing results immediately can be discouraging and cause people to give up too early. In this article, we look at the process of starting a home based business and working through the frustrations to be there when the sales come flowing in.
2: Why You Need To Build Multiple Streams of Income For Yourself
Being an entrepreneur and earning multiple streams of income is a dream that many have, but in reality it does take some initial hard work to achieve this. Earning multiple streams of income is the wave of the future, and here are some tips and advice for you when you are looking for ways in which to do this for yourself.
3: What is Cyber Marketing And Why It Is So Important For The Success Of Your Website
Cyber marketing has now become an indispensable segment of e-commerce as well as the internet and World Wide Web related topics. Cyber marketing simply refers to a technique of attracting potential customers by advertising your products or services through such means as websites, emails, and banners.
4: Article Marketing Strategy: Putting Together a "Class Schedule" For Your Article Topics
Businesses go to so much trouble when there is one sure-fire, simple, very inexpensive way to attract new clients to a business: Teach a free class. That is what article marketing is like. Your articles are just like free classes. You teach your target readers something helpful in your article. Your resource box then says, "If you enjoyed this article you can visit my website and apply what you have learned."
5: The Best Way To Optimise Your Website SEO For Google Panda
If you want your SEO to work you now need to concentrate on appeasing Google Panda, and to do this you need to know what Google Panda's spiders/bots will be looking for. Find out here how to search engine optimise your website for the latest Google Panda algorithm, and achieve the success you deserve.
>>>bonnie franklin
personified the struggling
single parent
in "one day at a time."
franklin
lost her battle with cancer on friday in her california home. diana alviar has more from
los angeles
. this is it this is life
>> reporter: flawed and single and an romano was no
june cleaver
.
>>i'm not married.
>>you are divorced?
>>yes, i am.
>>great.
>> reporter: bonnie franklin
's character on "one day at a time" was a first for a
prime time
sitcom. she talked about it in a
2005
pbs reunion special.
>>back in the '70s when we were doing this, across the country were
single parents
. yet, it hadn't been reflected on camera.
>> reporter: born bonnie gale
franklin
, she made her tv debut at 9.
franklin
's biggest impact was as mom to daughters julie played by
mckenzie phillips
and barbara played by valerie bert nelly.
>>steve asked me to go away with him for the weekend and i'm going.
>>great, mom. have a great time.
>>barbara? you don't understand. she's going to shack up.
>> reporter: "one day at a time" was
ground breaking
, in this case because
franklin
played a
single mom
with a very active dating life.
>>i guess it's been a long time since you had a man sleep over, huh?
>>no.
>>this is really the first time we saw a divorcee on television dating men and really trying to get her
love life
back in order after a failed marriage.
>> reporter: last september, she was diagnosed with pafrpg ree nk kree attic cancer.
>>my heart is breaking. bonnie is always one of the most important women in my life and was a second mother to me. phillips said shes with just full of light and love. and the man who cast
franklin
in her iconic role said "i was wrong. i thought life forces never die. bonnie was such a
life force
. bubbly, always up, the smile never left her face." a feisty feminist who inspired her fans.
You might say the week is never really done in consumer technology news. Your workweek, however, hopefully draws to a close at some point. This is the Weekly Roundup on Engadget, a quick peek back at the top headlines for the past 7 days -- all handpicked by the editors here at the site. Click on through the break, and enjoy.
filed under: Real Estate posted on March 2nd, 2013
Whether renting a home in Virginia Beach is better than buying depends on many important items which include:
Other important factors to consider that may sway you to buy in Virginia Beach:
Interest rates at historic lows ? calculate how much a 1% increase in rates might affect you in the future considering the increased payment over 30 years.
If the buying of the home is such a good deal then it may be prudent to purchase vice rent. That means very low to no down payment and closing cost assistance.
Do you not like being told what you can and cannot do to your home and yard (painting, landscaping, interior decorating, etc.) then buying may be better than renting.
Click the calculator below to get started
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This entry was posted on Saturday, March 2nd, 2013 at 8:07 am and is filed under Real Estate. You can follow any responses to this entry through the RSS 2.0 feed.
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Other important factors to consider that may sway you to buy in Virginia Beach:
